Article
A major gene influences variation in large HDL particles and their response to diet in baboons.
Atherosclerosis - 1 Aug 2002
Rainwater David L, Kammerer Candace M, Cox Laura A, Rogers Jeffrey, Carey K D, Dyke Bennett, Mahaney Michael C, McGill Henry C, VandeBerg John L
Abstract excerpt
Some baboons accumulate appreciable amounts of large apoE-rich HDLs (HDL(1)) which are similar to those reported in humans with several different dyslipoproteinemias. We estimated HDL(1) cholesterol concentrations by gradient gel electrophoresis of serum samples obtained from 634 pedigreed baboons fed with three diets differing in levels of fat and cholesterol. The HDL(1) trait was highly heritable on each diet...
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