Article
Multivariate segregation analysis using the mixed model.
Genetic epidemiology - 1 Jan 1991
Blangero J, Konigsberg L W
Abstract excerpt
Most major genes involved in the etiology of complex diseases are likely to have pleiotropic effects on a number of intervening quantitative traits. Methods of segregation analysis that incorporate the additional information from such multiple traits will exhibit greater power for detecting the effects of major genes and allow explicit tests of major locus pleiotropy hypotheses. In this study, we present a new...
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