Susceptibility genes for familial Alzheimer's disease on chromosomes 19 and 21: a reality check.

doi:10.1002/gepi.1370100616

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Article

Susceptibility genes for familial Alzheimer's disease on chromosomes 19 and 21: a reality check.

Genetic epidemiology - 1 Jan 1993

Farrer L A, Stice L

Abstract excerpt

Linkage data from 92 FAD kindreds were analyzed by lod score analysis under various assumptions of disease penetrance, marker allele frequencies, and heterogeneity. Multilocus linkage analysis supports the existence of a gene in 40%-65% of families with predominantly late-onset illness (after age...

Topics

Aged
Alleles
Alzheimer Disease
Chromosome Mapping
Chromosomes, Human, Pair 19
Chromosomes, Human, Pair 21
Family
Gene Frequency
Genetic Linkage
Genetic Markers
Genetic Predisposition to Disease
Humans
Middle Aged

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