Article
Genetic heterogeneity of gene defects responsible for familial Alzheimer disease.
Genetica - 1 Jan 1993
Tanzi R, Gaston S, Bush A, Romano D, Pettingell W, Peppercorn J, Paradis M, Gurubhagavatula S, Jenkins B, Wasco W
Abstract excerpt
Inherited Alzheimer's disease is a genetically heterogeneous disorder that involves gene defects on at least five chromosomal loci. Three of these loci have been found by genetic linkage studies to reside on chromosomes 21, 19, and 14. On chromosomes 21, the gene encoding the precursor protein of Alzheimer-associated amyloid (APP) has been shown to contain several mutations in exons 16 and 17 which account for...
Topics
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Chromosomes, Human
- Genes
- Genetic Linkage
- Humans
- Models, Biological
- Mutation