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Linkage analysis of familial Alzheimer disease, using chromosome 21 markers.

American journal of human genetics - 1 Mar 1991

Schellenberg G D, Pericak-Vance M A, Wijsman E M, Moore D K, Gaskell P C, Yamaoka L A, Bebout J L, Anderson L, Welsh K A, Clark C M

Abstract excerpt

Chromosome 21 markers were tested for linkage to familial Alzheimer disease (FAD) in 48 kindreds. These families had multiple cases of Alzheimer disease (AD) in 2 or more generations with family age-at-onset means (M) ranging from 41 to 83 years. Included in this group are seven Volga German families which are thought to be genetically homogeneous with respect to FAD. Autopsy documentation of AD was available for...

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PMID: 1998342
PMCID: PMC1682988

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