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Article

Linkage analysis of familial Alzheimer disease, using chromosome 21 markers.

American journal of human genetics - 1 Mar 1991

Schellenberg G D, Pericak-Vance M A, Wijsman E M, Moore D K, Gaskell P C, Yamaoka L A, Bebout J L, Anderson L, Welsh K A, Clark C M

Abstract excerpt

Chromosome 21 markers were tested for linkage to familial Alzheimer disease (FAD) in 48 kindreds. These families had multiple cases of Alzheimer disease (AD) in 2 or more generations with family age-at-onset means (M) ranging from 41 to 83 years. Included in this group are seven Volga German families which are thought to be genetically homogeneous with respect to FAD. Autopsy documentation of AD was available for...

Topics

Adult
Aged
Aged, 80 and over
Alzheimer Disease
Chromosomes, Human, Pair 21
Female
Genetic Linkage
Genetic Markers
Genotype
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Pedigree

Recombination, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 1998342
PMCID: PMC1682988

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1998342-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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