Article
Chromosome 14 and late-onset familial Alzheimer disease (FAD).
American journal of human genetics - 1 Sept 1993
Schellenberg G D, Payami H, Wijsman E M, Orr H T, Goddard K A, Anderson L, Nemens E, White J A, Alonso M E, Ball M J
Abstract excerpt
Familial Alzheimer disease (FAD) is genetically heterogeneous. Two loci responsible for early-onset FAD have been identified: the amyloid precursor protein gene on chromosome 21 and the as-yet-unidentified locus on chromosome 14. The genetics of late-onset FAD is unresolved. Maximum-likelihood, affected-pedigree-member (APM), and sib-pair analyses were used, in 49 families with a mean age at onset > or = 60...
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