Article
Is a single mutation at the same locus responsible for all affected cases in a large Alzheimer pedigree (FAD4)?
Genetic epidemiology - 1 Jan 1993
Martinez M, Campion D, Babron M C, Clerget-Darpoux F
Abstract excerpt
Analysis of marker segregation in the large Alzheimer pedigree, FAD4, leads to the conclusion, with a type I error of 5%, of linkage heterogeneity between two branches of the pedigree: the disease cosegregates with chromosome 21 markers flanking the APP area in one branch and not in the other one. Thus, we conclude that a single mutation in the chromosome 21 region surrounding APP cannot be responsible for all...
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