Article
Linkage of familial Alzheimer disease to chromosome 14 in two large early-onset pedigrees: effects of marker allele frequencies on lod scores.
American journal of medical genetics - 1 May 1993
Nechiporuk A, Fain P, Kort E, Nee L E, Frommelt E, Polinsky R J, Korenberg J R, Pulst S M
Abstract excerpt
Alzheimer disease (AD) is a devastating neurodegenerative disease leading to global dementia. In addition to sporadic forms of AD, familial forms (FAD) have been recognized. Mutations in the amyloid precursor protein (APP) gene on chromosome (CHR) 21 have been shown to cause early-onset AD in a small number of pedigrees. Recently, linkage to markers on CHR 14 has been established in several early-onset FAD...
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