Article
A locus on chromosome 9p confers susceptibility to ALS and frontotemporal dementia.
Neurology - 28 Mar 2006
Morita M, Al-Chalabi A, Andersen P M, Hosler B, Sapp P, Englund E, Mitchell J E, Habgood J J, de Belleroche J, Xi J, Jongjaroenprasert W, Horvitz H R, Gunnarsson L-G, Brown R H
Abstract excerpt
OBJECTIVE: To perform genetic linkage analysis in a family affected with ALS and frontotemporal dementia (FTD). METHODS: The authors performed a genome-wide linkage analysis of a four-generation, 50-member Scandinavian family in which five individuals were diagnosed with ALS and nine with FTD. Linkage calculations assuming autosomal dominant inheritance of a single neurodegenerative disease manifesting as either...
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