Article
Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease.
Human molecular genetics - 15 Nov 2007
Hamshere Marian L, Holmans Peter A, Avramopoulos Dimitrios, Bassett Susan S, Blacker Deborah, Bertram Lars, Wiener Howard, Rochberg Nan, Tanzi Rudolph E, Myers Amanda, Wavrant-De Vrièze Fabienne, Go Rodney, Fallin Daniele, Lovestone Simon, Hardy John, Goate Alison, O'Donovan Michael, Williams Julie, Owen Michael J
Abstract excerpt
Previous attempts to identify genetic loci conferring risk for late-onset Alzheimer's disease (LOAD) through linkage analysis have observed some regions of linkage in common. However, due to the sometimes-considerable overlap between the samples, some of these reports cannot be considered to be independent replications. In order to assess the strength of the evidence for linkage and to obtain the best indication...
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