Article
Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14.
Nature genetics - 1 Dec 1992
St George-Hyslop P, Haines J, Rogaev E, Mortilla M, Vaula G, Pericak-Vance M, Foncin J F, Montesi M, Bruni A, Sorbi S, Rainero I, Pinessi L, Pollen D, Polinsky R, Nee L, Kennedy J, Macciardi F, Rogaeva E, Liang Y, Alexandrova N, Lukiw W, Schlumpf K, Tanzi R, Tsuda T, Farrer L, Cantu J M, Duara R, Amaducci L, Bergamini L, Gusella J, Roses A, Crapper McLachlan D
Abstract excerpt
Familial Alzheimer's disease (FAD) has been shown to be genetically heterogeneous, with a very small proportion of early onset pedigrees being associated with mutations in the amyloid precursor protein (APP) gene on chromosome 21, and some late onset pedigrees showing associations with markers on chromosome 19. We now provide evidence for a major early onset FAD locus on the long arm of chromosome 14 near the...
Topics
- Aged
- Alleles
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Base Sequence
- Chromosome Mapping
- Chromosomes, Human, Pair 14
- DNA
- Female