Article
Linkage detection by the Affected-Pedigree-Member method: what is really tested?
Genetic epidemiology - 1 Jan 1993
Babron M C, Martinez M, Bonaïti-Pellié C, Clerget-Darpoux F
Abstract excerpt
We show that the null hypothesis in the Affected-Pedigree-Member (APM) method is composed of two sub-hypotheses: no linkage and correct marker allele distribution. As a result, the APM method is not robust to misspecification of marker allele frequencies.
Topics
- Alleles
- Alzheimer Disease
- Chromosome Aberrations
- Chromosome Disorders
- Chromosomes, Human, Pair 19
- Gene Frequency
- Genetic Linkage
- Genetic Markers
- Humans
- North Carolina
- Pedigree
- Statistics as Topic