Article
Regulated cleavage of Alzheimer beta-amyloid precursor protein in the absence of the cytoplasmic tail.
Neuroscience - 1 Dec 1993
da Cruz e Silva O A, Iverfeldt K, Oltersdorf T, Sinha S, Lieberburg I, Ramabhadran T V, Suzuki T, Sisodia S S, Gandy S, Greengard P
Abstract excerpt
Alzheimer beta-amyloid precursor protein can be phosphorylated on residues Thr654, Ser655 and Thr668 on its cytoplasmic domain. Proteolytic cleavage of the amyloid precursor protein and release of the amyloid precursor protein ectodomain into the medium of cultured cells can be activated by phorb...
Topics
- Amino Acid Sequence
- Amyloid beta-Protein Precursor
- Cell Line
- Cytoplasm
- Molecular Sequence Data
- Mutation
- Phorbol 12,13-Dibutyrate
- Phosphorylation
- Transfection