Article
Cleavage of Alzheimer's amyloid precursor protein (APP) by secretases occurs after O-glycosylation of APP in the protein secretory pathway. Identification of intracellular compartments in which APP cleavage occurs without using toxic agents that interfere with protein metabolism.
The Journal of biological chemistry - 13 Mar 1998
Tomita S, Kirino Y, Suzuki T
Abstract excerpt
beta-Amyloid peptide (Abeta) is a principal component of parenchymal amyloid deposits in Alzheimer's disease. Abeta is derived from amyloid precursor protein (APP) by proteolytic cleavage. APP is subject to N- and O-glycosylation and potential tyrosine sulfation, following protein synthesis, and...
Topics
- Alzheimer Disease
- Amyloid Precursor Protein Secretases
- Amyloid beta-Protein Precursor
- Aspartic Acid Endopeptidases
- Biological Transport
- Cell Compartmentation
- Endopeptidases
- Glycosylation
- Golgi Apparatus
- Humans
- Mutation
- Peptide Fragments
- Protein Processing, Post-Translational