Article
Fe65 is not involved in the platelet-derived growth factor-induced processing of Alzheimer's amyloid precursor protein, which activates its caspase-directed cleavage.
The Journal of biological chemistry - 16 Apr 2004
Zambrano Nicola, Gianni Davide, Bruni Paola, Passaro Fabiana, Telese Francesca, Russo Tommaso
Abstract excerpt
The proteolytic processing of the precursor of the beta-amyloid peptides (APP) is believed to be a key event in the pathogenesis of Alzheimer's disease. This processing is activated through a pathway involving the PDGF receptor, Src, and Rac1. In this paper, we demonstrate that this pathway specifically acts on APP and requires the YENPTY motif present in the APP cytosolic domain. Considering that several results...
Topics
- Alzheimer Disease
- Amino Acid Sequence
- Amyloid beta-Protein Precursor
- Animals
- Caspases
- Cell Line
- Humans
- Molecular Sequence Data
- Mutation
- Nerve Tissue Proteins