Article
A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein.
The Journal of biological chemistry - 4 Nov 2005
Hass Matthew R, Yankner Bruce A
Abstract excerpt
It has been proposed that gamma-secretase-mediated release of the amyloid precursor protein (APP) intracellular domain (AICD) results in nuclear translocation and signaling through a complex with the adaptor protein Fe65 and the histone acetyltransferase Tip60. Here, we show that APP and Fe65 activate transcription through a Gal4-Tip60 reporter in presenilin-1/2-deficient cells lacking generation of AICD. APP and...
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