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Article

Role of APP phosphorylation in FE65-dependent gene transactivation mediated by AICD.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Jun 2006

Nakaya Tadashi, Suzuki Toshiharu

Abstract excerpt

Consecutive cleavages of Alzheimer's amyloid beta-protein precursor (APP) generate intracellular domain fragment (AICD). Interaction of APP and/or AICD with the adaptor protein FE65 is thought to modulate the metabolism of APP and the function of AICD. Phosphorylation or amino acid substitution of APP and AICD at threonine 668 (Thr668) suppresses their association with FE65. Here, we analyzed the function of APP...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16716194
DOI: 10.1111/j.1365-2443.2006.00968.x

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of APP phosphorylation in FE65-dependent gene transactivation mediated by AICD.PMID 16716194Read ↗

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