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Article

Amyloid precursor protein truncated at any of the gamma-secretase sites is not cleaved to beta-amyloid.

Journal of neuroscience research - 1 Nov 1996

Paganetti P A, Lis M, Klafki H W, Staufenbiel M

Abstract excerpt

beta A4 secretion occurs upon processing of amyloid protein precursor (APP) by beta-secretase (N-terminus of beta A4) and gamma-secretase (C-terminus). To determine the sequence of these activities and the processing intermediate of beta A4, we expressed several truncated APP molecules in human HEK-293 cells. Immunofluorescence and biotinylation studies indicated that full-length APP or APP lacking the cytosolic...

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Source

Identifiers

PMID: 8933367
DOI: 10.1002/(SICI)1097-4547(19961101)46:3<283::AID-JNR1>3.0.CO;2-G

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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