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Article

Release of amino-terminal fragments from amyloid precursor protein reporter and mutated derivatives in cultured cells.

The Journal of biological chemistry - 15 Dec 1992

Sahasrabudhe S R, Spruyt M A, Muenkel H A, Blume A J, Vitek M P, Jacobsen J S

Abstract excerpt

Abnormal proteolytic processing of amyloid precursor protein (APP) is thought to be central to the formation and deposition of beta amyloid peptide in Alzheimer's disease. A putative "secretase" activity normally releases an amino-terminal APP fragment by cleaving APP at residues within the beta amyloid peptide thereby precluding amyloidogenesis. In order to better understand the requirements for APP cleavage by...

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Identifiers

PMID: 1281162

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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