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Article

Transforming growth factor-alpha and beta-amyloid precursor protein share a secretory mechanism.

The Journal of cell biology - 1 Feb 1995

Arribas J, Massagué J

Abstract excerpt

Cleavage and release of membrane protein ectodomains, a regulated process that affects many cell surface proteins, remains largely uncharacterized. To investigate whether cell surface proteins are cleaved through a shared mechanism or through multiple independent mechanisms, we mutagenized Chinese hamster ovary (CHO) cells and selected clones that were unable to cleave membrane-anchored transforming growth factor...

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Identifiers

PMID: 7844156
DOI: 10.1083/jcb.128.3.433
PMCID: PMC2120346

Genes

APP
TFG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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