Article
Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations.
The Journal of biological chemistry - 17 Jan 1997
Walter J, Capell A, Hung A Y, Langen H, Schnölzer M, Thinakaran G, Sisodia S S, Selkoe D J, Haass C
Abstract excerpt
The beta-amyloid precursor protein (betaAPP) is a transmembrane protein that is exclusively phosphorylated on serine residues within its ectodomain. To identify the cellular site of betaAPP phosphorylation, we took advantage of an antibody that specifically detects the free C terminus of beta-sec...
Topics
- Amyloid beta-Protein Precursor
- Cell Line
- Cell Membrane
- Golgi Apparatus
- Humans
- Mutation
- Phosphorylation
- Protein Kinases
- Subcellular Fractions