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Article

Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations.

The Journal of biological chemistry - 17 Jan 1997

Walter J, Capell A, Hung A Y, Langen H, Schnölzer M, Thinakaran G, Sisodia S S, Selkoe D J, Haass C

Abstract excerpt

The beta-amyloid precursor protein (betaAPP) is a transmembrane protein that is exclusively phosphorylated on serine residues within its ectodomain. To identify the cellular site of betaAPP phosphorylation, we took advantage of an antibody that specifically detects the free C terminus of beta-secretase-cleaved betaAPP containing the Swedish missense mutation (APPssw-beta). This antibody previously established the...

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Identifiers

PMID: 8999878
DOI: 10.1074/jbc.272.3.1896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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