Article
Endogenous beta-amyloid peptide synthesis modulates cAMP response element-regulated gene expression in PC12 cells.
Neuroscience - 1 Jan 2005
Echeverria V, Ducatenzeiler A, Chen C H, Cuello A C
Abstract excerpt
Extracellular-regulated kinases play a fundamental role in several neuroplasticity processes. In order to test whether endogenous beta-amyloid peptides play a role in the activation of extracellular-regulated kinase, we investigated the Rap1-extracellular-regulated kinase pathway in PC12 cells expressing human beta-amyloid precursor protein containing familial Alzheimer's disease mutations. In PC12 cells...
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