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Article

Clonotypic dominance and variable gene elements of pathogenic anti-DNA autoantibodies from a single patient with lupus.

Scandinavian journal of immunology - 1 Feb 1994

Chastagner P, Demaison C, Thèze J, Zouali M

Abstract excerpt

This study explores the usage and diversity of the variable gene elements expressed by human lupus antibodies to DNA bearing the 0-81 idiotype, a marker of pathogenic anti-DNA autoantibodies. Rather than studying DNA-specific clonotypes from different patients, a panel of idiotype positive anti-DNA autoantibody-secreting clones from a single individual were analysed. By cloning and nucleotide-sequencing the...

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Identifiers

PMID: 8296159
DOI: 10.1111/j.1365-3083.1994.tb03356.x

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