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Article

Lupus-specific antibodies reveal an altered pattern of somatic mutation.

15 Nov 1997

Abstract excerpt

The F4 idiotype is a heavy chain determinant expressed almost exclusively on IgG immunoglobulins and is highly associated with specificity for double-stranded DNA. Since high-titered F4 expression is present predominantly in sera of patients with systemic lupus erythematosus (SLE), we thought F4+ IgG antibodies might constitute a useful subset of immunoglobulins in which to investigate lupus-specific alterations...

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Identifiers

PMID: 9366568
DOI: 10.1172/jci119796

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Source receipt: pubmed, retrieved 7 Sept 2026.

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