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Article

Lupus anti-DNA antibodies bearing the 8.12 idiotype appear to be somatically mutated.

Journal of clinical immunology - 1 Jan 1992

Livneh A, Behar E, Many A, Ehrenfeld M, Gazit E, Diamond B

Abstract excerpt

Anti-DNA antibodies in systemic lupus erythematosus (SLE) sera were analyzed using an antiidiotype designated 8.12 which recognizes a determinant on lambda light chains highly expressed in SLE sera. Eight of ten normal individuals had peripheral blood lymphocytes which produced high-titered 8.12-positive antibodies, following transformation with Epstein Barr virus, implying that the 8.12-reactive sequence...

Topics

Antibodies, Antinuclear
Cell Line
Enzyme-Linked Immunosorbent Assay
Herpesvirus 4, Human
Humans
Immunoglobulin G
Immunoglobulin Idiotypes
Immunoglobulin M
In Vitro Techniques
Lupus Erythematosus, Systemic
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transformation, Genetic

Source

Identifiers

PMID: 1313042
DOI: 10.1007/BF00918267

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1313042-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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