Characterization of two human anti-DNA antibodies bearing the pathogenic idiotype 8.12.

doi:10.3109/08916939309010643

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Article

Characterization of two human anti-DNA antibodies bearing the pathogenic idiotype 8.12.

Autoimmunity - 1 Jan 1993

Paul E, Diamond B

Abstract excerpt

Antibodies against double stranded DNA (dsDNA) are characteristic of systemic lupus erythematosus (SLE) and have been implicated in disease pathogenesis. Up to one third of an SLE patient's anti-dsDNA antibodies can express the lambda L chain idiotype 8.12. Serum titers of this idiotype are eleva...

Topics

Amino Acid Sequence
Antibodies, Antinuclear
Base Sequence
DNA
Epitopes
Humans
Immunoglobulin Idiotypes
Lupus Erythematosus, Systemic
Molecular Sequence Data
Mutation

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