Article
Novel glycosylation of HLA-DRalpha disrupts antigen presentation without altering endosomal localization.
Journal of immunology (Baltimore, Md. : 1950) - 1 May 1998
Guerra C B, Busch R, Doebele R C, Liu W, Sawada T, Kwok W W, Chang M D, Mellins E D
Abstract excerpt
The HLA-DR hemizygous B lymphoblastoid cell line, 10.24.6, has a DRA mutation (Pro96-->Ser) that creates a novel glycosylation site at Asn94. The mutant DR molecules are primarily associated with nested fragments of invariant chain (class II-associated invariant chain peptides), and their interac...
Topics
- Antigen Presentation
- B-Lymphocytes
- Biological Transport
- Cell Line
- Endosomes
- Glycosylation
- HLA-DR Antigens
- Humans
- Mutation