Invariant-cognate peptide exchange restores class II dimer stability in HLA-DM mutants.

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Article

Invariant-cognate peptide exchange restores class II dimer stability in HLA-DM mutants.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 1994

Monji T, McCormack A L, Yates J R, Pious D

Abstract excerpt

Class II presentation mutants have mutations in the HLA-DMA or B genes and are defective in the presentation of whole exogenous Ags restricted by HLA-DR, -DQ, and -DP. The functional defect in Ag presentation is accompanied by an altered conformation of cell surface class II molecules and instabi...

Topics

Amino Acid Sequence
Antigen Presentation
B-Lymphocytes
Biopolymers
Blotting, Western
Cell Line
Chromatography, High Pressure Liquid
Electrophoresis, Polyacrylamide Gel
Epitopes
HLA-D Antigens
HLA-DR Antigens
Histocompatibility Antigens Class II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Hydrogen-Ion Concentration

Mass Spectrometry

Molecular Sequence Data

Mutation

Protein Binding

Source

Open in PubMed

Identifiers

PMID: 7525705

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7525705-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Invariant-cognate peptide exchange restores class II dimer stability in HLA-DM mutants.PMID 7525705Read ↗

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Amino acid substitutions in the putative MHC class II "dimer of dimers" interface inhibit CD4+ T cell activation.Semantic proximity Read ↗

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Modulation of HLA-DQ binding properties by differences in class II dimer stability and pH-dependent peptide interactions.Semantic proximity Read ↗

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