Article
Immunohistochemical analysis of the Brachyury protein in wild-type and mutant mouse embryos.
Developmental biology - 1 Jan 1994
Kispert A, Herrmann B G
Abstract excerpt
The murine Brachyury (T) gene is required in posterior mesoderm formation and axial development. Mutant embryos lacking T gene function are deficient in notochord differentiation and posterior mesoderm formation, but make anterior mesoderm. Posterior axial development requires increasing T activity along the rostrocaudal axis. The T gene is transiently transcribed in nascent and migrating mesoderm and...
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