Article
Is there a Brachyury the Second? Analysis of a transgenic mutation involved in notochord maintenance in mice.
Developmental biology - 1 Nov 1995
Rennebeck G M, Lader E, Chen Q, Bohm R A, Cai Z S, Faust C, Magnuson T, Pease L R, Artzt K
Abstract excerpt
A new phenotype mapping to the t-complex, which is designated Brachyury the Second (T2), is characterized by a slightly shortened tail in heterozygotes and homozygous failure to form an organized notochord with subsequent abnormal development of posterior somites and neural tube. The phenotype of T2 superficially resembles that of Brachyury; however, there are several important differences. Brachyury homozygotes...
Topics
- Animals
- Crosses, Genetic
- DNA
- DNA-Binding Proteins
- Embryo, Mammalian
- Embryonic and Fetal Development
- Fetal Proteins
- Gene Expression
- Genes, Lethal
- Genes, MHC Class I
- H-2 Antigens