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Article

A cell autonomous function of Brachyury in T/T embryonic stem cell chimaeras.

Nature - 26 Sept 1991

Rashbass P, Cooke L A, Herrmann B G, Beddington R S

Abstract excerpt

Developmental genetics has shown that the Brachyury (T) gene has a key role in mesoderm formation during gastrulation in the mouse. Homozygous embryos have a defective allantois, degenerate or absent notochord and disrupted primitive streak and node. The neural tube is kinked and somite formation interrupted. The T gene has been cloned and is expressed during the early stages of gastrulation, being restricted to...

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Source

Identifiers

PMID: 1922339
DOI: 10.1038/353348a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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A cell autonomous function of Brachyury in T/T embryonic stem cell chimaeras.PMID 1922339Read ↗

Brachyury--a gene affecting mouse gastrulation and early organogenesis.Semantic proximity Read ↗

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Use of chimeras to study gene function in mesodermal tissues during gastrulation and early organogenesis.Semantic proximity Read ↗

Putative oncogene Brachyury ( T ) is essential to specify cell fate but dispensable for notochord progenitor proliferation and EMTSemantic proximity Read ↗

The T-box gene family.Semantic proximity Read ↗

Is there a Brachyury the Second? Analysis of a transgenic mutation involved in notochord maintenance in mice.Semantic proximity Read ↗

Expression pattern of the Brachyury gene in whole-mount TWis/TWis mutant embryos.Semantic proximity Read ↗

Cloning of the T gene required in mesoderm formation in the mouse.Semantic proximity Read ↗

Effects of the TWis mutation on notochord formation and mesodermal patterning.Semantic proximity Read ↗

Mutation watch: mouse brachyury (T), the T-box gene family, and human disease.Semantic proximity Read ↗

Rescue of the tail defect of Brachyury mice.Semantic proximity Read ↗

no tail (ntl) is the zebrafish homologue of the mouse T (Brachyury) gene.Semantic proximity Read ↗

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