Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A cell autonomous function of Brachyury in T/T embryonic stem cell chimaeras.

Nature - 26 Sept 1991

Rashbass P, Cooke L A, Herrmann B G, Beddington R S

Abstract excerpt

Developmental genetics has shown that the Brachyury (T) gene has a key role in mesoderm formation during gastrulation in the mouse. Homozygous embryos have a defective allantois, degenerate or absent notochord and disrupted primitive streak and node. The neural tube is kinked and somite formation interrupted. The T gene has been cloned and is expressed during the early stages of gastrulation, being restricted to...

Topics

Animals
Chimera
Chromosome Deletion
Embryo, Mammalian
Embryonic and Fetal Development
Glucose-6-Phosphate Isomerase
Mesoderm
Mice
Mice, Inbred C57BL
Mutation
Phenotype
Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1922339
DOI: 10.1038/353348a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1922339-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A cell autonomous function of Brachyury in T/T embryonic stem cell chimaeras.PMID 1922339Read ↗

Brachyury--a gene affecting mouse gastrulation and early organogenesis.Semantic proximity Read ↗

Expression of T protein in the primitive streak is necessary and sufficient for posterior mesoderm movement and somite differentiation.Semantic proximity Read ↗

Use of chimeras to study gene function in mesodermal tissues during gastrulation and early organogenesis.Semantic proximity Read ↗

Putative oncogene Brachyury ( T ) is essential to specify cell fate but dispensable for notochord progenitor proliferation and EMTSemantic proximity Read ↗

The T-box gene family.Semantic proximity Read ↗

Is there a Brachyury the Second? Analysis of a transgenic mutation involved in notochord maintenance in mice.Semantic proximity Read ↗

Expression pattern of the Brachyury gene in whole-mount TWis/TWis mutant embryos.Semantic proximity Read ↗

Cloning of the T gene required in mesoderm formation in the mouse.Semantic proximity Read ↗

Effects of the TWis mutation on notochord formation and mesodermal patterning.Semantic proximity Read ↗

Mutation watch: mouse brachyury (T), the T-box gene family, and human disease.Semantic proximity Read ↗

Rescue of the tail defect of Brachyury mice.Semantic proximity Read ↗

no tail (ntl) is the zebrafish homologue of the mouse T (Brachyury) gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.