Article
In vivo knockdown of Brachyury results in skeletal defects and urorectal malformations resembling caudal regression syndrome.
Developmental biology - 1 Dec 2012
Pennimpede Tracie, Proske Judith, König Andrea, Vidigal Joana A, Morkel Markus, Bramsen Jesper B, Herrmann Bernhard G, Wittler Lars
Abstract excerpt
The T-box transcription factor BRACHYURY (T) is a key regulator of mesoderm formation during early development. Complete loss of T has been shown to lead to embryonic lethality around E10.0. Here we characterize an inducible miRNA-based in vivo knockdown mouse model of T, termed KD3-T, which exhibits a hypomorphic phenotype. KD3-T embryos display axial skeletal defects caused by apoptosis of paraxial mesoderm,...
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