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Article

Immunohistochemical assessment of MGMT expression and p53 mutation in glioblastoma multiforme.

Tumori - 1 Jan 2000

Lotfi Marziyeh, Afsharnezhad Sima, Raziee Hamid Reza, Ghaffarzadegan Kamran, Sharif Samaneh, Shamsara Jamal, Lary Sara, Behravan Javad

Abstract excerpt

AIMS AND BACKGROUND: The prognosis of glioblastoma multiforme (GBM) remains poor despite advances in surgery and adjuvant therapies. TP53 and O6-methylguanine-DNA methyltransferase (MGM) are tumor suppressor genes that are implicated in GBM resistance to radiation and chemotherapy. In order to assess the expression of the protein products of these two genes, 50 GBM samples were analyzed in this study. METHODS:...

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Share to Brain Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Enzymologic

Share to Glioblastoma

Share to Predictive Value of Tests

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 21528672
DOI: 10.1177/030089161109700118

Genes

MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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