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Article

Cellular epigenetics: topochronology of progressive "spontaneous" transformation of cells under growth constraint.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jan 1994

Chow M, Yao A, Rubin H

Abstract excerpt

Early passages of NIH 3T3 cells yield about 10 transformed foci for every 10(5) cells seeded after the cells multiply to confluence in a standardized 2-week assay. The question arose whether more cells would give rise to foci if given more time for their development. This question could not be answered simply by extending the incubation period, since the original foci spread to cover much of the area of the...

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Identifiers

PMID: 8290570
DOI: 10.1073/pnas.91.2.599
PMCID: PMC42996

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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