Article
Relation of the slow growth phenotype to neoplastic transformation: possible significance for human cancer.
In vitro cellular & developmental biology. Animal - 1 Sept 1999
Chow M, Rubin H
Abstract excerpt
Deletions are widely distributed over the genome in the most frequently occurring human cancers and are the most abundant genetic lesion found there. Deletions are highly correlated with the slow growth phenotype of mutated animal and human cells and result in chromosomal transposition when the retained ends are joined. Transpositions are only a minor source of mutation in rapidly multiplying bacteria but are a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.