Article
Inheritance of phenotype in mammalian cells: genetic vs. epigenetic mechanisms.
The American journal of physiology - 1 Jun 1991
Gruenert D C, Cozens A L
Abstract excerpt
Inherited phenotypic changes in cultured cells, as observed during differentiation and transformation, reflect alterations in gene expression and have both a genetic and epigenetic basis. The causes of specific changes are often difficult to define especially when observing phenomenological end points. Although such observations are an important step in defining the phenotypic changes that endure for multiple...
Topics
- Animals
- Cell Differentiation
- Cell Division
- Cell Transformation, Neoplastic
- Cells, Cultured
- Gene Amplification
- Humans
- Karyotyping
- Phenotype