Effect of interclonal heterogeneity on the progressive, confluence-mediated acquisition of the focus-forming phenotype in NIH-3T3 populations.

Abstract excerpt

Confluence is an agent that promotes the progressive acquisition of the focus forming phenotype in clones of cells within NIH-3T3 populations. This conclusion is based on four results. (a) Even in cultures which have been confluent for more than 2 weeks without making foci, some cells in those cultures have been affected by the confluent state and will make foci if replated and allowed to grow into new saturated...

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