Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Degrees and kinds of selection in spontaneous neoplastic transformation: an operational analysis.

Proceedings of the National Academy of Sciences of the United States of America - 28 Jun 2005

Rubin Harry

Abstract excerpt

Spontaneous neoplastic transformation develops within days in the NIH 3T3 line of cells through differential inhibition of their proliferation under contact inhibition. A small fraction of the population continues to multiply after saturation density is reached and is selected to progressively increase saturation density in successive rounds of confluence. The degree of selection at confluence depends on the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Culture Techniques
Share to Cell Count
Share to Cell Line, Transformed

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Lineage

Share to Cell Transformation, Neoplastic

Share to Culture Media

Share to NIH 3T3 Cells

Share to Recurrence

Source

Open in PubMed Open full text

Identifiers

PMID: 15967983
DOI: 10.1073/pnas.0503688102
PMCID: PMC1166625

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Degrees and kinds of selection in spontaneous neoplastic transformation: an operational analysis.PMID 15967983Read ↗

Cell-cell contact interactions conditionally determine suppression and selection of the neoplastic phenotype.Semantic proximity Read ↗

Phenotypic selection as the biological mode of epigenetic conversion and reversion in cell transformation.Semantic proximity Read ↗

Cell Competition in Carcinogenesis.Semantic proximity Read ↗

'Spontaneous' transformation as aberrant epigenesis.Semantic proximity Read ↗

Cellular epigenetics: topochronology of progressive "spontaneous" transformation of cells under growth constraint.Semantic proximity Read ↗

Adaptation and selection as factors in the spontaneous transformation of NIH-3T3 cells.Semantic proximity Read ↗

Models of tumor-host interaction as competing populations: implications for tumor biology and treatment.Semantic proximity Read ↗

Cell Competition Spurs Selection of Aggressive Cancer Cells.Semantic proximity Read ↗

Relation of the slow growth phenotype to neoplastic transformation: possible significance for human cancer.Semantic proximity Read ↗

The transcriptional programme of contact‐inhibitionSemantic proximity Read ↗

Sequential oncogenic mutations influence cell competition.Semantic proximity Read ↗

Fields and field cancerization: the preneoplastic origins of cancer: asymptomatic hyperplastic fields are precursors of neoplasia, and their progression to tumors can be tracked by saturation density in culture.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.