Article
Non-selective analysis of the transformation of FR3T3 rat cells by bovine papillomavirus type 1: regulations of viral transcription associated with phenotypic transformation.
Oncogene - 1 Nov 1990
Binétruy B, Schiller J, Lowy D, Cerni C, Cuzin F
Abstract excerpt
Drug-resistant clones selected from FR3T3 rat cells after transfer of neo-BPV1 (Bovine Papillomavirus Type 1) DNA constructs became phenotypically transformed (focal transformation, growth in suspension and tumor formation) soon after selection (approximately 5 generations in culture). A frameshift mutation in ORF E5 abolished transformation, but did not prevent the autonomous maintenance of the DNA construct. A...
Topics
- Animals
- Bovine papillomavirus 1
- Cell Line
- Cell Transformation, Neoplastic
- Cell Transformation, Viral
- DNA, Viral
- Fibroblasts
- Gene Expression Regulation
- Genes, Viral
- Mutation
- Phenotype