Selective nature of phorbol 12-myristate 13-acetate-induced neoplastic transformation in NIH 3T3 cells.

doi:10.1073/pnas.91.6.2320

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Article

Selective nature of phorbol 12-myristate 13-acetate-induced neoplastic transformation in NIH 3T3 cells.

Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 1994

Rubin A L, Rubin H

Abstract excerpt

The ability of phorbol 12-myristate 13-acetate (PMA) at 0.02 microgram/ml to induce neoplastic transformation in NIH 3T3 cells is highly dependent on the culture conditions. Optimal transformation, indicated by the saturation density and extent of focus formation in transferred cultures raised un...

Topics

3T3 Cells
Animals
Cell Division
Cell Transformation, Neoplastic
Culture Media
Mice
Phenotype
Tetradecanoylphorbol Acetate

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