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Article

'Spontaneous' transformation as aberrant epigenesis.

Differentiation; research in biological diversity - 1 Jun 1993

Rubin H

Abstract excerpt

The NIH 3T3 line of cells has particular advantages for studying the dynamics of change in cellular phenotype in response to environmental conditions. Similar to stem cell growth during development, the cell line changes its phenotype under growth constraints that elicit differentiation or, alternatively, it maintains its original state over many replication cycles when grown without constraint. Unlike many cell...

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PMID: 8359592
DOI: 10.1111/j.1432-0436.1993.tb00652.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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