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Article

Phenotypic selection as the biological mode of epigenetic conversion and reversion in cell transformation.

Proceedings of the National Academy of Sciences of the United States of America - 23 Jan 2018

Rubin Harry, Rubin Andrew L

Abstract excerpt

Exposure of certain cell lines to methylcholanthrene, X-rays, or physiological growth constraint leads to preneoplastic transformation in all or most of the treated cells. After attaining confluence, a fraction in those cells progress to full transformation, as evidenced by their ability to form discrete foci distinguishable from the surrounding cells by virtue of their higher density. Transformation induced by...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29311337
DOI: 10.1073/pnas.1717299115
PMCID: PMC5789940

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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