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Article

Metal-responsive transcription factor-1 (MTF-1) is essential for embryonic liver development and heavy metal detoxification in the adult liver.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 2004

Wang Ying, Wimmer Ursula, Lichtlen Peter, Inderbitzin Daniel, Stieger Bruno, Meier Peter J, Hunziker Lukas, Stallmach Thomas, Forrer Rhea, Rülicke Thomas, Georgiev Oleg, Schaffner Walter

Abstract excerpt

Metal-responsive transcription factor-1 (MTF-1) activates the transcription of metallothionein genes and other target genes in response to heavy metal load and other stresses such as hypoxia and oxidative stress. It also has an essential function during embryogenesis: targeted disruption of Mtf1 in the mouse results in lethal liver degeneration on day 14 of gestation. Here we studied Mtf1 knockout mice at...

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PMID: 15226267
DOI: 10.1096/fj.03-1282com

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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