Article
Gene expression profiling in wild-type and metallothionein mutant fibroblast cell lines.
Biological research - 1 Jan 2006
Armendáriz Angela D, Olivares Felipe, Pulgar Rodrigo, Loguinov Alex, Cambiazo Veronica, Vulpe Christopher D, González Mauricio
Abstract excerpt
The role of metallothioneins (MT) in copper homeostasis is of great interest, as it appears to be partially responsible for the regulation of intracellular copper levels during adaptation to extracellular excess of the metal. To further investigate a possible role of MTs in copper metabolism, a genomics approach was utilized to evaluate the role of MT on gene expression. Microarray analysis was used to examine...
Topics
- Animals
- Cell Line
- Copper
- Fibroblasts
- Fluorescent Antibody Technique
- Gene Expression Profiling
- Homeostasis
- Metallothionein
- Mice
- Microarray Analysis
- Mutation