Article
Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3' kinase.
Oncogene - 1 Feb 1994
Wennström S, Siegbahn A, Yokote K, Arvidsson A K, Heldin C H, Mori S, Claesson-Welsh L
Abstract excerpt
Activation of the platelet-derived growth factor (PDGF) beta-receptor results in motility responses in the forms of membrane ruffling and chemotaxis. Porcine aortic endothelial cells expressing the PDGF beta-receptor or a chimeric fibroblast growth factor (FGF) receptor, in which the endogenous kinase insert was replaced with the corresponding region from the PDGF beta-receptor, migrated efficiently towards a...
Topics
- Animals
- Binding Sites
- Cell Line
- Cell Membrane
- Cell Movement
- Chemotaxis
- DNA
- Endothelium, Vascular
- Mutation
- Phosphatidylinositol 3-Kinases
- Phosphorylation
- Phosphotransferases (Alcohol Group Acceptor)
- Protein-Tyrosine Kinases
- Receptors, Platelet-Derived Growth Factor