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Article

Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3' kinase.

Oncogene - 1 Feb 1994

Wennström S, Siegbahn A, Yokote K, Arvidsson A K, Heldin C H, Mori S, Claesson-Welsh L

Abstract excerpt

Activation of the platelet-derived growth factor (PDGF) beta-receptor results in motility responses in the forms of membrane ruffling and chemotaxis. Porcine aortic endothelial cells expressing the PDGF beta-receptor or a chimeric fibroblast growth factor (FGF) receptor, in which the endogenous kinase insert was replaced with the corresponding region from the PDGF beta-receptor, migrated efficiently towards a...

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PMID: 8290276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3' kinase.PMID 8290276Read ↗

Mutation of a Src phosphorylation site in the PDGF beta-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis.Semantic proximity Read ↗

Mutation of tyrosine residue 857 in the PDGF beta-receptor affects cell proliferation but not migration.Semantic proximity Read ↗

PDGF alpha-receptor mediated cellular responses are not dependent on Src family kinases in endothelial cells.Semantic proximity Read ↗

Beta PDGF receptor mutants defective for mitogenesis promote neurite outgrowth in PC12 cells.Semantic proximity Read ↗

Autoinhibition of the platelet-derived growth factor beta-receptor tyrosine kinase by its C-terminal tail.Semantic proximity Read ↗

Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling.Semantic proximity Read ↗

EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration.Semantic proximity Read ↗

Deletion of the kinase insert sequence of the platelet-derived growth factor beta-receptor affects receptor kinase activity and signal transduction.Semantic proximity Read ↗

Regulation of chemotaxis by the platelet-derived growth factor receptor-beta.Semantic proximity Read ↗

v-Src accelerates spontaneous motility via phosphoinositide 3-kinase, phospholipase C and phospholipase D, but abrogates chemotaxis in Rat-1 and MDCK cells.Semantic proximity Read ↗

Proliferation versus migration in platelet-derived growth factor signaling: the key role of endocytosis.Semantic proximity Read ↗

Evidence for distinct signaling properties and biological responses induced by the PDGF receptor alpha and beta subtypes.Semantic proximity Read ↗

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