Deletion of the kinase insert sequence of the platelet-derived growth factor beta-receptor affects receptor kinase activity and signal transduction.

doi:10.1128/mcb.10.2.801-809.1990

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Article

Deletion of the kinase insert sequence of the platelet-derived growth factor beta-receptor affects receptor kinase activity and signal transduction.

Molecular and cellular biology - 1 Feb 1990

Severinsson L, Ek B, Mellström K, Claesson-Welsh L, Heldin C H

Abstract excerpt

A characteristic feature of the platelet-derived growth factor (PDGF) beta-receptor is the presence of an insert sequence in the protein tyrosine kinase domain. A receptor mutant which lacks the entire insert of 98 amino acids was expressed in CHO cells, and its functional characteristics were compared with those of the wild-type receptor. The mutant receptor bound PDGF-BB with high affinity and mediated...

Topics

Animals
Cell Line
Chromosome Deletion
Cloning, Molecular
DNA Transposable Elements
Gene Expression
Genes
Genetic Vectors
Humans
Kinetics
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphorylation

Plasmids

Platelet-Derived Growth Factor

Protein Kinases

Protein-Tyrosine Kinases

Proto-Oncogene Proteins

Proto-Oncogene Proteins c-fos

Source

Open in PubMed Open full text

Identifiers

PMID: 2153924
DOI: 10.1128/mcb.10.2.801-809.1990
PMCID: PMC360881

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2153924-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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