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Article

Proliferation versus migration in platelet-derived growth factor signaling: the key role of endocytosis.

The Journal of biological chemistry - 18 Jul 2008

De Donatis Alina, Comito Giusy, Buricchi Francesca, Vinci Maria C, Parenti Astrid, Caselli Anna, Camici Guido, Manao Giampaolo, Ramponi Giampietro, Cirri Paolo

Abstract excerpt

It is common knowledge that platelet-derived growth factor (PDGF) is a critical regulator of mesenchymal cell migration and proliferation. Nevertheless, these two cellular responses are mutually exclusive. To solve this apparent contradiction, we studied the behavior of NIH3T3 fibroblasts in response to increasing concentrations of PDGF. We found that there is strong cell proliferation induction only with PDGF...

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Source

Identifiers

PMID: 18499659
DOI: 10.1074/jbc.M709428200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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