Article
Mutation of a Src phosphorylation site in the PDGF beta-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis.
The EMBO journal - 1 Oct 1996
Hansen K, Johnell M, Siegbahn A, Rorsman C, Engström U, Wernstedt C, Heldin C H, Rönnstrand L
Abstract excerpt
Ligand induced activation of the beta-receptor for platelet-derived growth factor (PDGF) leads to activation of Src family tyrosine kinases. We have explored the possibility that the receptor itself is a substrate for Src. We show that Tyr934 in the kinase domain of the PDGF receptor is phosphory...
Topics
- Actins
- Amino Acid Sequence
- Becaplermin
- Cell Division
- Cell Line
- Chemotaxis
- Chromones
- Enzyme Inhibitors
- HeLa Cells
- Humans
- Isoenzymes
- Kinetics
- Molecular Sequence Data
- Morpholines
- Mutation
- Peptides
- Phosphatidylinositol 3-Kinases
- Phospholipase C gamma