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Article

Autoinhibition of the platelet-derived growth factor beta-receptor tyrosine kinase by its C-terminal tail.

The Journal of biological chemistry - 7 May 2004

Chiara Federica, Bishayee Subal, Heldin Carl-Henrik, Demoulin Jean-Baptiste

Abstract excerpt

In this report, we investigated the role of the C-terminal tail of the platelet-derived growth factor (PDGF) beta-receptor in the control of the receptor kinase activity. Using a panel of PDGF beta-receptor mutants with progressive C-terminal truncations, we observed that deletion of the last 46 residues, which contain a proline- and glutamic acid-rich motif, increased the autoactivation velocity in vitro and the...

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Identifiers

PMID: 14996833
DOI: 10.1074/jbc.M314070200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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