PDGF alpha-receptor mediated cellular responses are not dependent on Src family kinases in endothelial cells.

doi:10.1242/jcs.111.5.607

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Article

PDGF alpha-receptor mediated cellular responses are not dependent on Src family kinases in endothelial cells.

Journal of cell science - 1 Mar 1998

Hooshmand-Rad R, Yokote K, Heldin C H, Claesson-Welsh L

Abstract excerpt

Two novel autophosphorylation sites in the juxtamembrane region of the PDGF alpha-receptor, Tyr-572 and Tyr-574, were identified. A Y572/574F mutant PDGF (alpha)-receptor was generated and stably expressed in porcine aortic endothelial cells. In contrast to the wild-type receptor, the mutant rece...

Topics

Actins
Amino Acid Sequence
Cell Line
Endothelium, Vascular
Molecular Sequence Data
Mutation
Phosphorylation
Receptors, Platelet-Derived Growth Factor
Thymidine
Tritium
Tyrosine
src-Family Kinases

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